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KMID : 0624620170500070355
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BMB Reports
2017 Volume.50 No. 7 p.355 ~ p.360
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Structure, signaling and the drug discovery of the Ras oncogene protein
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Han Chang-Woo
Jeong Mi-Suk
Jang Se-Bok
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Abstract
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Mutations in Ras GTPase are among the most common genetic alterations in human cancers. Despite extensive research investigating Ras proteins, their functions still remain a challenge over a long period of time. The currently available data suggests that solving the outstanding issues regarding Ras could lead to development of effective drugs that could have a significant impact on cancer treatment. Developing a better understanding of their biochemical properties or modes of action, along with improvements in their pharmacologic profiles, clinical design and scheduling will enable the development of more effective therapies.
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KEYWORD
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Inhibitor, Mutation, Ras, Signaling
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